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Claire Seedhouse Selected Research

Proteins (Proteins, Gene)

1/2022Protein Kinase C Epsilon Overexpression Is Associated With Poor Patient Outcomes in AML and Promotes Daunorubicin Resistance Through p-Glycoprotein-Mediated Drug Efflux.
1/2015Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy.
6/2011P-glycoprotein and breast cancer resistance protein in acute myeloid leukaemia cells treated with the aurora-B kinase inhibitor barasertib-hQPA.

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Claire Seedhouse Research Topics

Disease

13Neoplasms (Cancer)
01/2022 - 07/2004
7Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2022 - 11/2002
4Breast Neoplasms (Breast Cancer)
12/2018 - 06/2011
4Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal)
05/2017 - 01/2014
3Endometrial Neoplasms (Endometrial Cancer)
05/2017 - 01/2014
2Leukemia
10/2018 - 12/2007
2Genomic Instability
05/2014 - 07/2004
2Ovarian Neoplasms (Ovarian Cancer)
06/2013 - 01/2013
2Ataxia Telangiectasia (Louis Bar Syndrome)
04/2013 - 01/2013
1Noninfiltrating Intraductal Carcinoma (DCIS)
12/2018
1Weight Loss (Weight Reduction)
04/2015
1Melanoma (Melanoma, Malignant)
05/2014
1Endometrial Hyperplasia
01/2014
1Hypersensitivity (Allergy)
03/2013
1Ataxia (Dyssynergia)
03/2013
1Residual Neoplasm
09/2012
1Polyploidy
03/2010
1Myelodysplastic Syndromes (Myelodysplastic Syndrome)
07/2004

Drug/Important Bio-Agent (IBA)

5Pharmaceutical PreparationsIBA
05/2014 - 12/2007
3Proteins (Proteins, Gene)FDA Link
01/2022 - 06/2011
3Cisplatin (Platino)FDA LinkGeneric
01/2015 - 01/2013
3DNA (Deoxyribonucleic Acid)IBA
01/2015 - 03/2013
2Metformin (Glucophage)FDA LinkGeneric
04/2015 - 01/2014
2LDL CholesterolIBA
04/2015 - 12/2007
2Messenger RNA (mRNA)IBA
01/2015 - 05/2014
2lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA
01/2015 - 03/2013
2Biomarkers (Surrogate Marker)IBA
05/2014 - 06/2013
2Aurora Kinase BIBA
06/2011 - 03/2010
2Member 1 Subfamily B ATP Binding Cassette TransporterIBA
06/2011 - 12/2007
2Aurora KinasesIBA
06/2011 - 03/2010
1Protein Isoforms (Isoforms)IBA
01/2022
1CateninsIBA
06/2019
1olaparibIBA
12/2018
1ABT-737IBA
10/2018
1venetoclaxIBA
10/2018
1SterolsIBA
05/2017
1LipidsIBA
05/2017
1ElementsIBA
05/2017
1Triglycerides (Triacylglycerol)IBA
05/2017
1Insulin (Novolin)FDA Link
03/2016
1Cyclin D2IBA
04/2015
1Blood Glucose (Blood Sugar)IBA
04/2015
1EndonucleasesIBA
05/2014
1TensinsIBA
05/2014
1Doxycycline (Periostat)FDA LinkGeneric
05/2014
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
05/2014
1X-ray Repair Cross Complementing Protein 1IBA
06/2013
1PlatinumIBA
06/2013
1RNA Polymerase II (RNA Polymerase B)IBA
06/2013
1RNA (Ribonucleic Acid)IBA
06/2013
1Interleukin-23 (Interleukin 23)IBA
04/2013
1Phosphotransferases (Kinase)IBA
04/2013
12- morpholin- 4- yl- 6- thianthren- 1- yl- pyran- 4- oneIBA
03/2013
11,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA
03/2013
1PyransIBA
03/2013
1Estrogen ReceptorsIBA
03/2013
1Hormones (Hormone)IBA
03/2013
1BenzopyransIBA
03/2013
18- dibenzothiophen- 4- yl- 2- morpholin- 4- yl- chromen- 4- oneIBA
03/2013
1Protein Kinases (Protein Kinase)IBA
01/2013
1Single-Stranded DNA (DNA, Single Stranded)IBA
01/2013
14- cyclohexylmethoxy- 5- nitrosopyrimidine- 2,6- diamineIBA
01/2013
1tipifarnib (R115777)IBA
09/2012
1AZD 1152-HQPAIBA
06/2011
1Histones (Histone)IBA
03/2010
1Serine (L-Serine)FDA Link
03/2010
1Clofarabine (Clolar)FDA Link
12/2009
1LDL Lipoproteins (beta Lipoproteins)IBA
12/2007
1Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
12/2007
1NADP (NADPH)IBA
07/2004
1quinone (benzoquinone)IBA
07/2004
1Oxidoreductases (Dehydrogenase)IBA
07/2004

Therapy/Procedure

6Therapeutics
04/2015 - 11/2002
3Drug Therapy (Chemotherapy)
10/2018 - 07/2004
1Chemoprevention
12/2018